Anti-filarial activity of novel formulations of albendazole against experimental brugian filariasis
Identifieur interne : 007A82 ( Main/Exploration ); précédent : 007A81; suivant : 007A83Anti-filarial activity of novel formulations of albendazole against experimental brugian filariasis
Auteurs : R. L. Gaur [Inde] ; S. Dixit [Inde] ; M. K. Sahoo [Inde] ; M. Khanna [Inde] ; S. Singh [Inde] ; P. K. Murthy [Inde]Source :
- Parasitology [ 0031-1820 ] ; 2007-04.
Abstract
The study was aimed at developing better orally active albendazole (ALB) formulations. Six formulations (ALB-1 to ALB-6) were prepared and tested against Brugia malayi in Mastomys coucha and jird (Meriones unguiculatus) at 200 mg/kg, orally, for 5 consecutive days. The anti-filarial efficacy was assessed against microfilariae (mf), adult worms and female reproductive potential. Three of the 6 ALB formulations showed greatly improved female worm sterilizing potential (ALB-1: 90%; ALB-3: 63%; ALB-4: 77% of untreated control) in B. malayi – M. coucha model. Sterilization efficacy of ALB-1 was also better than that shown by pure-ALB (P<0·001) or its marketed tablet formulation, Zentel (P<0·01), while that of ALB-4 was better than pure-ALB (P<0·05). The activity of ALB-3, pure-ALB and Zentel was, however, comparable. ALB-1 also showed late microfilaricidal activity with a maximum of 78% fall in microfilarial count. In contrast, neither the pure ALB nor Zentel showed any microfilaricidal activity. In the jird – B. malayi model, ALB-1 and ALB-4 showed marginal sterilizing efficacy whereas pure ALB or Zentel were ineffective. In conclusion the anti-filarial efficacy of ALB-1 was found to be superior to pure-ALB or Zentel.
Url:
DOI: 10.1017/S0031182006001612
Affiliations:
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Murthy</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Parasitology, Central Drug Research Institute, Lucknow, 226001</wicri:regionArea><wicri:noRegion>226001</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Parasitology</title><idno type="ISSN">0031-1820</idno><idno type="eISSN">1469-8161</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="2007-04">2007-04</date><biblScope unit="volume">134</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="537">537</biblScope><biblScope unit="page" to="544">544</biblScope></imprint><idno type="ISSN">0031-1820</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0031-1820</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The study was aimed at developing better orally active albendazole (ALB) formulations. Six formulations (ALB-1 to ALB-6) were prepared and tested against Brugia malayi in Mastomys coucha and jird (Meriones unguiculatus) at 200 mg/kg, orally, for 5 consecutive days. The anti-filarial efficacy was assessed against microfilariae (mf), adult worms and female reproductive potential. Three of the 6 ALB formulations showed greatly improved female worm sterilizing potential (ALB-1: 90%; ALB-3: 63%; ALB-4: 77% of untreated control) in B. malayi – M. coucha model. Sterilization efficacy of ALB-1 was also better than that shown by pure-ALB (P<0·001) or its marketed tablet formulation, Zentel (P<0·01), while that of ALB-4 was better than pure-ALB (P<0·05). The activity of ALB-3, pure-ALB and Zentel was, however, comparable. ALB-1 also showed late microfilaricidal activity with a maximum of 78% fall in microfilarial count. In contrast, neither the pure ALB nor Zentel showed any microfilaricidal activity. In the jird – B. malayi model, ALB-1 and ALB-4 showed marginal sterilizing efficacy whereas pure ALB or Zentel were ineffective. In conclusion the anti-filarial efficacy of ALB-1 was found to be superior to pure-ALB or Zentel.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Gaur, R L" sort="Gaur, R L" uniqKey="Gaur R" first="R. L." last="Gaur">R. L. Gaur</name></noRegion><name sortKey="Dixit, S" sort="Dixit, S" uniqKey="Dixit S" first="S." last="Dixit">S. Dixit</name><name sortKey="Khanna, M" sort="Khanna, M" uniqKey="Khanna M" first="M." last="Khanna">M. Khanna</name><name sortKey="Murthy, P K" sort="Murthy, P K" uniqKey="Murthy P" first="P. K." last="Murthy">P. K. Murthy</name><name sortKey="Sahoo, M K" sort="Sahoo, M K" uniqKey="Sahoo M" first="M. K." last="Sahoo">M. K. Sahoo</name><name sortKey="Singh, S" sort="Singh, S" uniqKey="Singh S" first="S." last="Singh">S. Singh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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